One of the largest topics in the library: the modifiable factors behind male fertility and sperm quality.
This study set out to understand how lifestyle factors relate to semen abnormalities in men undergoing fertility evaluation in Ghana. It analyzed medical records of 221 men at a Ghanaian…
This study looked at whether ozone (a reactive gas in smog, formed when pollution meets sunlight) affects semen quality in lower-income men with unhealthy lifestyle habits (think smoking, heavy drinking,…
This study looked at how occupational heat exposure and fertility-related stress might affect semen quality. It compared 485 men, split into groups with normal and low semen quality based on…
This study looked at whether eating ultra-processed food around the time of conception affects fertility and early embryo development in couples. It followed 831 women and 651 men from before…
This systematic review set out to examine how phthalates, chemicals widely used to soften plastics and to carry fragrance in cosmetics, affect male fertility by altering semen quality. It pulled…
This study set out to explore whether the mix of bacteria in semen differs between men with normal and abnormal sperm counts. Researchers analyzed semen samples from 80 Greek men,…
This study set out to see if sperm quality changes with the seasons in Denmark and Florida, and whether outdoor temperatures play a role. It looked at semen samples from…
This review looked at how nutrition shapes male fertility at the cellular level, focusing on how nutrients affect sperm production, function, and DNA. It pulled together human, animal, and lab…
This review set out to explore how environmental factors affect sperm quality and male fertility. It analyzed 82 recent studies, mostly from 2020 onward, looking at pollutants, heat, radiation, and…
This study measured how outdoor temperature tracks with semen quality, using records from 5,114 men attending a reproductive medicine centre in Wenzhou, on China's east coast. The measure it used…
This review looked at whether the underwear a man wears, tight versus loose, actually affects his fertility. The testicles work best a little cooler than the rest of the body,…
This systematic review set out to assess how GLP-1 receptor agonists (a class of diabetes and weight-loss drugs) affect male reproductive hormones, semen quality, and metabolic health. It pooled data…
This study set out to understand how folic acid affects sperm health, especially in the context of inflammation in the reproductive tract. It looked at 98 men, measuring their red…
This study looked at whether the intensity of physical activity affects semen quality in men who already have impaired sperm health. It followed over 1,300 men undergoing fertility evaluations, each…
This study set out to review how different weight loss methods affect male fertility in men with obesity. It looked at 32 studies that compared lifestyle changes, medications, and bariatric…
This review looked at how psychological stress might affect male fertility through oxidative stress. It synthesized animal studies and human observational data to explore the link between stress, oxidative damage,…
This study aimed to assess how much adult men know about male fertility, focusing on medical and lifestyle factors that affect it. Researchers surveyed 156 men of reproductive age using…
This study set out to see if physical fitness is linked to semen quality in Spanish men. Researchers analyzed semen samples from 324 men without known fertility issues, comparing self-reported…
This study set out to examine how modifiable lifestyle factors like smoking, drinking, and weight affect semen quality in men. It analyzed data from over 3,300 men visiting a fertility…
This study set out to explore how coffee, exercise, and sleep relate to semen quality in men. It surveyed 3,302 men aged 18-60, collecting semen samples and lifestyle data through…
This study looked at whether the quality and amount of carbohydrates in a man's diet affect sperm DNA damage, a common problem in unexplained infertility. Researchers compared 300 Iranian men…
This study set out to examine whether astaxanthin (a potent antioxidant) could improve sperm quality after freezing and thawing. It pooled data from multiple studies to see how astaxanthin affected…
This study set out to examine how exposure to fine particulate air pollution (PM2.5) and its components affects semen quality, and whether living near green spaces might help protect against…
This review set out to examine how microplastics (tiny plastic particles) affect the male reproductive system at the cellular and molecular level. It compiled findings from multiple studies across scientific…
Researchers followed 1,220 men at a Utah fertility clinic and matched the outdoor heat and humidity each man lived through while his sperm were forming against a molecular measure of…
This study tested whether CoQ10, L-carnitine (an amino-acid-like nutrient the body uses to turn fat into energy), or both together improve semen quality in men with low sperm count, poor…
This umbrella review (a review of other reviews) set out to catalogue what damages male fertility. It gathered 43 systematic reviews and meta-analyses published between 2000 and 2025, covering 67…
This study set out to see if taking oral medications or zinc supplements affects zinc levels in the blood and whether that links to better sperm health or fertility outcomes…
This study set out to evaluate whether botulinum toxin injections near the scrotum or testicles affect male fertility. It reviewed animal studies and human case reports, focusing on outcomes like…
This study looked at how different measures of obesity relate to semen quality in men from infertile couples who had no other known fertility risks. It compared body mass index…
This review examined how oxidative stress, sperm DNA damage, and epigenetic changes interact to affect male fertility. It pulled together studies on men with infertility, looking at how these factors…
This study looked at how eating patterns relate to sperm quality in healthy young men. Researchers scored the diets of 200 men against several patterns, healthy ones like the Mediterranean…
This study looked at whether a heart-healthy lifestyle is linked to better sperm quality in young men, using the American Heart Association's Life's Essential 8 score. That score rates eight…
This review set out to explore how dietary fatty acids (FAs) affect sperm quality and male fertility. It looked at recent studies on how different FAs influence sperm production and…
This study looked at whether dietary polyphenols (plant antioxidants found in fruits, vegetables, tea, and olive oil) are linked to semen quality in young men. It analyzed 3-day diet records…
This study asked whether the pandemic changed how sensitive sperm production is to weather. It took 2,672 semen analyses from 1,287 Korean men collected between 2018 and 2024 and matched…
This review looked at how oxidative stress (cell damage from unstable molecules called reactive oxygen species, a normal byproduct of metabolism that turns harmful when it outpaces the body's defenses)…
This review gathers recent evidence on what damages male fertility and how much of it can be undone. Smoking raises sperm DNA fragmentation (breaks in the genetic material inside sperm)…
This systematic review and meta-analysis set out to see whether dietary supplements improve male fertility. It pooled 50 randomised trials in which men took a supplement for at least 12…
This narrative review set out to explore how oxidative stress (an imbalance between harmful reactive oxygen species and the body's defenses) affects fertility in men and women, and whether dietary…
This study looked at how lifestyle and hormones affect semen quality and sperm DNA health in men. It examined 278 Indian men aged 21 to 50, measuring sperm count, movement,…
The 2025 European Association of Urology (EAU) guidelines aimed to update recommendations on diagnosing and treating male infertility, based on a structured review of new evidence. The panel assessed studies…
This study looked at whether obesity speeds up the decline in sperm quality that has been seen over time. Researchers reviewed semen tests from 2,430 men with normal sperm counts…
This study looked at whether vitamin D3 supplementation improves hormone levels and semen quality in infertile men. It pooled data from six randomized controlled trials involving 945 men, measuring changes…
This scoping review set out to map the evidence on how psychosocial work factors affect male fertility and sperm quality. It analyzed 18 peer-reviewed studies from 1990 to 2024, focusing…
This review set out to examine whether mobile phones and laptops, as sources of electromagnetic radiation and heat, might harm male fertility by affecting semen quality. It analyzed existing studies,…
This study set out to identify which factors might influence pregnancy success in couples undergoing assisted reproductive technology (ART, fertility treatments that handle eggs and sperm outside the body). It…
This narrative review set out to explore how lifestyle choices affect male fertility, examining diet, exercise, stress, sleep, weight, and environmental exposures. It synthesized existing research on how these factors…
This study set out to see if microplastics (tiny plastic particles) are present in human semen and whether they might affect sperm health. Researchers analyzed semen samples from 45 men…
This review set out to examine how heavy metals like lead, mercury, and cadmium affect sperm quality and male fertility, focusing on their role in oxidative stress and antioxidant imbalance.…
This study looked at how diet relates to sperm quality, comparing the Mediterranean diet, which is built on seasonal, fresh and whole foods, against ultra-processed foods, which are high in…
This study looked at whether exposure to air pollution, especially fine particles (PM2.5 and PM10), affects semen quality in men. It included 1,180 men aged 18, 45 from Foshan, China,…
This meta-analysis (a study that statistically pools many earlier studies) looked at how body mass index (BMI, a weight-for-height number used to flag over- or under-weight) relates to sperm quality…
This study set out to see how often men ejaculate affects their sperm health, focusing on DNA damage and other semen measures. It looked at 1,349 men visiting a fertility…
This study set out to see if sticking to a Mediterranean diet (MedDiet) is linked to better sperm quality and fertility outcomes in men. It pooled data from 11 studies,…
This study set out to see how lifestyle and insulin resistance relate to male fertility. Insulin resistance means the body has stopped responding properly to insulin, so it takes more…
This scoping review aimed to assess how diet before conception affects male fertility and reproductive outcomes. It analyzed 37 studies, including one randomized controlled trial and 36 observational studies, published…
This narrative review set out to explore the link between sperm DNA fragmentation (breaks in the genetic material inside sperm) and male infertility. It pooled findings from 28 studies, looking…
This study set out to see whether microplastics turn up in semen in ordinary men with no plastics job, and whether they track with sperm quality. Researchers took semen from…
This study set out to see whether microplastics in the body track with sperm quality. Researchers checked semen and urine from 113 men across three regions of China for eight…
This review set out to explore how polystyrene microplastics (PS-MPs) might harm male fertility by damaging the blood-testis barrier (BTB), a protective shield in the testicles that keeps harmful substances…
This narrative review argues that a man's fertility is a readable signal of his health generally, not just of his ability to father a child. The reasoning runs like this:…
This study looked at whether sleep duration affects markers of male fertility in young men. It analyzed 1,055 Danish men who reported their sleep habits and gave semen and blood…
This systematic review set out to assess whether following a Mediterranean diet affects sperm quality in men of reproductive age. It analyzed 10 studies involving over 2,000 men aged 18-55,…
This 2024 update to the American Urological Association (AUA) and American Society for Reproductive Medicine (ASRM) guideline reviewed new evidence on male infertility to refine recommendations for evaluation and management.…
This systematic review and meta-analysis set out to assess whether coenzyme Q10 (CoQ10) supplementation improves semen quality and male hormone levels. It pooled data from eight randomized controlled trials involving…
This study set out to clarify how bisphenol A (BPA, a chemical used in food packaging and container linings) affects men's reproductive health. It pooled 18 studies that measured BPA…
This study looked at whether following a Mediterranean diet is linked to better semen quality in men visiting fertility clinics. It compared semen parameters across 274 men grouped by how…
This is a narrative review, which means the authors gathered and discussed existing work rather than running a study of their own. It asks whether the damage COVID-19 does to…
This systematic review and meta-analysis set out to find which lifestyle, environmental and health factors go with higher sperm DNA fragmentation, meaning breaks in the genetic material inside sperm, where…
This meta-analysis set out to examine how alcohol intake affects male reproductive health by looking at semen quality, antioxidant levels in semen, sperm DNA damage, and sex hormones. It pooled…
This study looked at whether following a Mediterranean diet (MD) is linked to healthier sperm in men. Researchers surveyed 300 men (average age 35) visiting a reproductive medicine center, using…
This study set out to examine global trends in sperm count over the past several decades. It pooled data from 223 studies, including semen samples collected from men worldwide between…
This meta-analysis set out to work out how high ambient temperature affects sperm quality. It pooled nine studies covering 356 men in Iran, Italy, Thailand, China and Egypt, comparing men…
This study asked whether a man's heat exposures affect how quickly his partner conceives, which is a harder and more useful question than whether they affect a semen sample. It…
This study set out to find out whether men actually use scrotal cooling devices as directed, and what happened to their semen results when they did. Forty men attending a…
This study tested whether a specially designed cooling garment could lower scrotal skin temperature during ordinary daily life. Three volunteer urologists wore it, with a cold pack inside that was…
This study set out to find which stage of sperm production is most sensitive to mild heat. Five healthy volunteers wore a specially designed underwear that held the testicles up…
This study set out to see whether N-acetyl-cysteine (NAC, an antioxidant supplement, taken here at 600 mg a day) improves sperm quality in infertile men. Fifty infertile men with poor…
This study set out to explore how sperm DNA fragmentation (breaks in the genetic material inside sperm, more breaks mean a lower chance of conception and live birth, so lower…
This study asked what a mild, sustained rise in testicular temperature does to the chromosomes inside sperm. Five fertile volunteers wore specially designed underwear that held the testicles up against…
This meta-analysis set out to see whether omega-3 fats improve sperm in infertile men. It pooled three randomized trials, 147 men on omega-3 and 143 on control treatments, and measured…
This review pulled together what is known about how everyday life affects a man's fertility, covering age, psychological stress, nutrition, physical activity, caffeine, scrotal temperature, hot water and mobile phone…
This study looked at whether the type of underwear men wear affects markers of testicular function, such as sperm count and hormone levels. Researchers surveyed 656 men seeking fertility treatment…
This systematic review set out to test the health claims made for regular dry sauna use, because the claims are common and the evidence behind them had never been gathered…
This is a history of forty years of French research into male contraception (hormonal, chemical and thermal) summarising clinical trials involving thousands of men and couples. Those trials established that…
This study set out to see whether zinc in semen is linked to male infertility and whether zinc supplements improve sperm. It pooled 20 studies, comparing zinc levels and sperm…
This experiment followed what whole-body heat does to sperm as they are made, in laboratory mice. Adult males were held at 37 to 38 degrees Celsius (98.6 to 100.4 degrees…
This study set out to see what repeated heat does to sperm. Twenty men with normal semen results were randomly split into two groups, and both had their testicles warmed…
This study looked at how sleep duration relates to semen quality and reproductive hormones in young men. It recruited 796 male college students in Chongqing, China and followed up 656…
This study set out to see what sustained scrotal heating does to semen and to the sperm's genetic material in fertile men. Nineteen healthy volunteers wore a warming belt at…
This study looked at what sustained scrotal heating does to semen and to the sperm's genetic material in already fertile men. Twenty-five healthy volunteers wore a warming belt at 40…
This review gathers what is known about why heat harms sperm production, and how. It sets out the things that raise testicular temperature, from the surroundings a man is in…
This study set out to see how regular sauna use affects sperm health in men whose sperm counts were normal to begin with. Ten men used a Finnish sauna twice…
This study set out to work out which sperm DNA fragmentation test best predicts male infertility. Sperm DNA fragmentation means breaks in the genetic material inside sperm, where more breaks…
This review set out to gather what is known about whether cooling the scrotum helps sperm production. The authors searched two large medical databases, EMBASE from 1980 to 2010 and…
This study looked at whether poor sleep affects semen quality in young men. It surveyed 953 healthy Danish men aged around military-service age, asking about their sleep patterns and measuring…
This meta-analysis set out to see if coenzyme Q10 (CoQ10) supplements improve male fertility, focusing on live birth and pregnancy rates, sperm concentration, and sperm motility. It pooled data from…
This study tested ways to prevent scrotal overheating in men using laptop computers. Twenty-nine healthy men had their scrotal temperature measured during three one-hour sessions: sitting with legs close together,…
This experiment asked whether heat reaches sperm that have already been made, rather than only the ones still forming. Fourteen C57BL/6 mice (a laboratory strain bred so that individuals within…
This study looked at whether N-acetylcysteine (NAC), an antioxidant supplement, could improve semen quality and oxidative stress in men with unexplained infertility. It randomly assigned 120 men with idiopathic infertility…
It has been suggested that cycling warms the testicles as a ride goes on, and that this in turn harms semen quality. This study tested the first half of that…
This review looked at how heat stress on the testicles affects semen quality in men. It examined studies on factors like prolonged sitting, tight underwear, sauna use, and fever, and…
This study looked at whether stopping hot tubs, hot baths and whirlpools improves semen quality in infertile men. Eleven men with a regular wet heat habit were assessed before and…
This experiment asked whether heat makes sperm worse at their actual job, or simply leaves fewer of them. Male mice were held at 36 degrees Celsius (96.8 degrees Fahrenheit) for…
This study looked at whether cooling the scrotum overnight improves semen quality in men with a history of undescended testicles and a low sperm count, a group with few options…
This study set out to measure how much using a laptop on your lap raises scrotal temperature, a known risk factor for male infertility. Researchers measured scrotal temperature in 29…
This study looked at what a fever does to semen quality in healthy men. Twenty-seven men with a median age of 24.4 years gave a semen sample every month and…
This study set out to look at how scrotal temperature affects semen quality in healthy men. It tracked 99 men over 24 hours, measuring scrotal skin temperature continuously and collecting…
This study asked why men differ so much in how warm their testicles run. Scrotal skin temperature was logged every five minutes for 24 hours in 48 men, made up…
This study set out to find which parts of an ordinary day actually move scrotal temperature. A thermistor (a small temperature sensor) was clipped to the underwear of 101 men…
This study looked at whether reducing genital heat could improve semen quality in men with a poor sperm count, poor movement and abnormal shape. It compared those men against men…
This study asked whether the ordinary, everyday variation in scrotal temperature is enough to matter for sperm. Sixty men from a group of couples planning their first pregnancy wore a…
This lecture is the field's own summary of why the testicles sit outside the body and what happens when they get warm. It sets out the evidence that the testes…
This study looked at whether cooling the testicles every day helps men whose couples had been unable to conceive. It followed 64 men who had subfertile semen and a raised…
This study set out to test whether cooling the scrotum could improve semen in men with a low sperm count or poor sperm movement. Fifty such men wore jockey shorts…
This study looked at whether cooling the scrotum could improve semen quality in men whose infertility came with a raised testicular temperature. Six men with poor semen results and a…