Comparative Efficacy and Pharmacokinetic Parameters of Micronized Creatine Monohydrate (KleanCREATINE™) in Active Men: A Randomized, Controlled Clinical Study.

Plain-language summary

This study set out to compare a micronized form of creatine monohydrate (KleanCREATINE™) with a standard creatine supplement in active men. It had two parts: first, a small test in healthy men to see how the body absorbs and processes the creatine, and second, an eight-week trial in active men measuring strength, endurance, muscle growth, and body fat. The micronized creatine was absorbed faster and more fully, and over eight weeks it led to bigger gains in muscle, strength, and endurance, with less perceived effort during workouts, compared to the standard creatine. Both forms were safe, with no side effects reported.

Key findings

• Micronized creatine had higher peak blood levels (8.10 vs 4.80 nmol/UI) and faster absorption (2 vs 3 hours) than standard creatine.
• After eight weeks, men taking micronized creatine saw greater muscle growth (10.46%), fat loss (14.45%), and chest press endurance (60.05% vs 49.29%).
• Perceived exertion dropped more with micronized creatine (26.4% vs 13.46%).
• Both forms were safe, with no reported side effects.