Meta AnalysisHumann = 945 subjects2025China
Impact of Vitamin D3 Supplementation on Androgens and Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis Based on Prospective Randomised Controlled Trials.
Plain-language summary
This study looked at whether vitamin D3 supplementation improves hormone levels and semen quality in infertile men. It pooled data from six randomized controlled trials involving 945 men, measuring changes in testosterone, SHBG (sex hormone-binding globulin, a protein that binds testosterone and sets how much is free and usable), total sperm count, and sperm motility. Vitamin D3 did not clearly raise testosterone or SHBG. It was, though, linked to higher total sperm count and a higher share of moving sperm.
Key findings
- Vitamin D3 supplementation did not significantly increase testosterone levels in infertile men.
- Vitamin D3 supplementation did not significantly increase SHBG levels.
- Vitamin D3 supplementation was linked to higher total sperm counts.
- Vitamin D3 supplementation was linked to a higher percentage of motile sperm.
How to analyze the study yourself
- Study type
- Meta-analyses pool data from multiple studies for greater statistical power, but the quality depends on the included studies' designs and consistency.
- Population
- The study focused on infertile men, so results may not generalize to all men.
- Funding
- Not reported
- Watch for
- This study found that vitamin D3 did not raise testosterone but was linked to higher sperm count and motility in infertile men. If you are struggling with infertility, it may be worth taking vitamin D3.