Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials.

Plain-language summary

This systematic review and meta-analysis set out to assess whether coenzyme Q10 (CoQ10) supplementation improves semen quality and male hormone levels. It pooled data from eight randomized controlled trials involving 877 men, comparing men who took CoQ10 to those given a placebo or nothing. CoQ10 was linked to higher total sperm counts, better motility, and more normally shaped sperm, along with higher testosterone and higher inhibin B (a hormone from the testicles that reflects sperm-producing capacity where higher generally signals healthier sperm production). It had no clear effect on semen volume or sperm concentration.

Key findings

• CoQ10 supplementation was linked to higher total sperm counts.
• CoQ10 improved total and progressive sperm motility.
• CoQ10 increased the proportion of normally shaped sperm.
• CoQ10 was tied to higher serum testosterone and inhibin B levels.
• CoQ10 did not affect semen volume or sperm concentration.