European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2025 Update on Male Infertility.

Plain-language summary

The 2025 European Association of Urology (EAU) guidelines aimed to update recommendations on diagnosing and treating male infertility, based on a structured review of new evidence. The panel assessed studies from major medical databases to develop practical advice, focusing on thorough urological assessments and shared decision-making with the female partner. The guidelines now include new sections on exome sequencing (a genetic test that reads the protein-coding stretches of DNA, where most disease-causing faults sit) and probiotic use, alongside updated evidence for diagnosing male infertility.

Key findings

• Emphasizes thorough urological assessment for men with fertility issues
• Stresses parallel investigation of the female partner for shared decision-making
• Recommends counseling infertile men on associated health risks
• Adds new sections on exome sequencing and probiotic treatment