Working Against the Clock: Depression and Hormonal Imbalance in Shift-Working Men.

Plain-language summary

This study looked at how depression, testosterone levels, and shift work are linked in men with symptoms of low testosterone. It reviewed medical records and survey data from 766 men visiting a urology clinic, measuring testosterone levels, depression scores (using the PHQ-9), and sleep issues tied to shift work. It found that higher testosterone levels were tied to lower depression scores, and men at low risk for shift work sleep disorder had less depression and suicidal thoughts than those at high risk. The study highlights the importance of screening for depression in men with low testosterone symptoms, especially those working shifts.

Key findings

• Higher testosterone levels were linked to lower depression scores.
• Shift work appeared to worsen the relationship between low testosterone and depression.