Meta AnalysisHuman2026China

The effects of exercise interventions on bone mineral density in middle-aged and older men: a systematic review and meta-analysis.

Journal: Frontiers in physiologyPublished: 2026DOI: 10.3389/fphys.2026.1825374

Plain-language summary

This study set out to assess how exercise affects bone mineral density (BMD) in middle-aged and older men, focusing on different skeletal sites. It pooled data from randomized controlled trials to compare the impact of exercise programs on BMD. The results showed that exercise significantly increased BMD at the lumbar spine and femoral neck, areas prone to fractures, but not at the total hip or other cortical-dominant regions. The benefits were strongest with training frequencies of at least three sessions per week, durations over six months, and multicomponent exercise routines.

Key findings

  • Exercise increased bone mineral density at the lumbar spine and femoral neck in middle-aged and older men.
  • No significant BMD improvements were seen at the total hip or other cortical-dominant bone sites.
  • The best results came from exercising ≥3 times per week, continuing for >6 months, and using mixed exercise types.

How to analyze the study yourself

Study type
Meta-analyses pool results from multiple studies to spot patterns, but the quality depends on the included studies and how similar they are.
Population
Middle-aged and older men, exact age range not specified.
Funding
Not reported
Watch for
This study found that regular exercise, especially multicomponent routines done at least three times a week for over six months, can boost bone density in the spine and hip areas most prone to fractures. If you are middle-aged or older, it may be worth adding strength training and varied exercises to your routine to protect your bones.