Cross SectionalHumann = 5,7522026

Lower fat-free mass is independently linked to restless legs syndrome in men: a cross-sectional PSG-BIA study.

Journal: Frontiers in neurologyPublished: 2026DOI: 10.3389/fneur.2026.1749591

Plain-language summary

This study set out to explore whether lower muscle mass is linked to restless legs syndrome (RLS), a condition that disrupts sleep. Researchers analyzed data from 5,752 adults who underwent sleep studies and body composition scans, comparing muscle mass measures between those with and without RLS. They found that men with lower muscle mass had higher odds of RLS, while this link was not as strong in women. The results suggest that maintaining muscle mass might be particularly relevant for managing RLS in men.

Key findings

  • RLS was more common in women (6.6%) than men (2.9%).
  • Men with lower muscle mass had higher odds of RLS.
  • The link between muscle mass and RLS was stronger in men than women.

How to analyze the study yourself

Study type
Cross-sectional studies can identify associations but cannot determine cause and effect.
Population
Adults undergoing sleep studies at a tertiary sleep center.
Funding
Not reported
Watch for
This study found that men with lower muscle mass were more likely to have restless legs syndrome. If you experience RLS, it may be worth focusing on strength training to preserve muscle mass.